Best tool to compress a transparent png file to its smallest

I've played around with the usual optipng, pngcrush, advpng but by far the best results are found with pngquant which is actually a lossy compressor.

Depending on the settings the "loss" can be invisible so you get the benefits of a small file with none of the drawbacks.

pngquant --quality=65-80

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Oliver Polden